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A comment on this article appears in " Improving the long-term management of benign thyroid nodules. Share this article Share with Share with twitterShare with linkedinShare with facebook Abstract Detection of asymptomatic thyroid nodules has increased.

Consensus is lacking regarding the optimal follow-up of cytologically proven benign lesions and sonographically nonsuspicious nodules. Current guidelines recommend serial ultrasound examinations and reassessment of cytology if ificant growth is observed. To determine the frequency, magnitude, and factors associated with changes in thyroid nodule size.

Prospective, multicenter, observational study involving consecutive patients with 1 to 4 asymptomatic, sonographically or cytologically benign thyroid nodules.

Patients were recruited from 8 hospital-based thyroid-disease referral centers in Italy between and Data collected during the Kinky sex date in Hilmar CA. Swingers, kinkycouples 5 years of follow-up, through Januarywere analyzed.

Baseline nodule growth primary end point was assessed with yearly thyroid ultrasound examinations. Baseline factors associated with growth were identified.

Secondary end points were the sonographic detection of new nodules and the diagnosis of thyroid cancer during follow-up. Nodule growth occurred in patients One hundred seventy-four of the original nodules Nodule growth was associated with presence of multiple nodules OR, 2.

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An incidental cancer was found at thyroidectomy in a nonvisualized nodule. New nodules developed in 93 patients 9. Among patients with asymptomatic, sonographically or cytologically benign thyroid nodules, the majority of nodules exhibited no ificant size increase during 5 years of follow-up and thyroid cancer was rare.

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These findings support consideration of revision of current guideline recommendations for follow-up of Free sex bogor thyroid nodules.

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The natural history of benign thyroid nodules.

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